5 edition of Oxidative damage to nucleic acids found in the catalog.
Oxidative damage to nucleic acids
Includes bibliographical references and index.
|Statement||[edited by] Mark D. Evans, Marcus S. Cooke.|
|Series||Molecular biology intelligence unit, Molecular biology intelligence unit (Unnumbered)|
|Contributions||Evans, Mark D. 1962-, Cooke, Marcus S.|
|LC Classifications||QP620 .O95 2007|
|The Physical Object|
|LC Control Number||2007024908|
Potential factors for RNA quality control[ edit ] There have been furious debates on whether the issue of RNA quality control does exist. Hydrogen peroxide is produced by a wide variety of enzymes including several oxidases. Carnosine: A versatile antioxidant and antiglycating agent. However, with the concern of various lengths of half lives of diverse RNA species ranging from several minutes to hours, degradation of defective RNA can not easily be attributed to its transient character anymore.
Neurosci Lett ; — Reactive oxygen species play important roles in cell signalling, a process termed redox signaling. In addition to some of the traditionally covered topics, we have included some areas that receive less attention in similar volumes, for example chapters focusing on damage to nucleic acids by halogenating and nitrating species, gene-specific damage, telomere shortening and damage to promoter regions. The chapters are authored by leading, research active, international experts in the respective topics. Chem Res Toxicol ; —
Thus 8-oxo-dG, if not repaired, can directly cause frequent mutations, some of which may contribute to carcinogenesis. Preview Unable to display preview. Antioxid Redox Signal ; — Thus, to maintain proper cellular homeostasisa balance must be struck between reactive oxygen production and consumption. Marcus also worked his way through the ranks to become a tenured non-clinical senior lecturer in CSMM, but also holds a joint appointment in the world renowned Department of Genetics at Leicester, home of DNA fingerprinting.
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It begins with the mechanisms of radical production, antioxidant defense, pathogenesis, and recent biomarkers of oxidative stress in CKD patients.
These biopsies were taken Oxidative damage to nucleic acids book patients with chronic hepatitis C, a condition causing oxidative damages in the liver. Under these conditions, the selective pressure of oxidative stress is thought to have driven the evolutionary transformation of an archaeal lineage into the first eukaryotes.
Indeed, reaction with ROS takes only few minutes, which is even shorter than the average life-span of the most unstable RNAs. Thus 8-oxo-dG, if not repaired, can directly cause frequent mutations, some of which may contribute to carcinogenesis.
This cascade includes both strokes and heart attacks. Oxidative stress generated by the reducing Oxidative damage to nucleic acids book uric acid may be involved in the Lesch-Nyhan syndrome, strokeand metabolic syndrome.
Other enzymes that have antioxidant properties though this is not their primary role include paraoxonase, glutathione-S transferases, and aldehyde dehydrogenases. Oxidative stress has also been implicated in chronic fatigue syndrome.
Formation of etheno adducts in reactions of enals via autoxidation. The level of 8-oxo-dG was graded in the nuclei of colonic crypt cells on a scale of Immune defense Edit The immune system uses the lethal effects of oxidants by making production of oxidizing species a central part of its mechanism of killing pathogens; with activated phagocytes producing both ROS and reactive nitrogen species.
However, AstraZeneca 's radical scavenging nitrone drug NXY shows some efficacy in the treatment of stroke. The level of oxidative stress that a cell endures is reflected by the quantity of reactive oxygen species ROS. In the present review, besides discussing recent evidence underscoring the thesis that the Nrf2-ARE signalling pathway is an attractive therapeutic target for neurodegenerative diseases, we advocate the view that chemopreventive agents might be suitable candidates to serve as lead compounds for the development of a new class of neuroprotective drugs.
Mutagenesis by acrolein-derived propanodeoxyguanosine adducts in human cells. Blair IA. The first figure in this section shows a CpG site where the cytosine is methylated to form 5-methylcytosine 5mC and the guanine is oxidized to form 8-oxo-2'-deoxyguanosine in the figure this is shown in the tautomeric form 8-OHdG.
Besides its abundance, 8-hydroxydeoxyguanosine 8-oxodG and 8-hydroxyguanosine 8-oxoG are identified as the most detrimental oxidation lesions for their mutagenic effect,  in which this non-canonical counterpart can faultily pair with both adenine and cytosine at the same efficiency.
This promoter methylation could have reduced expression of these tumor suppressor genes and contributed to carcinogenesis. J Neurochem ; — Evidence indicating a role of oxidative DNA damage in schizophrenia has been reviewed by Raza et al. Although alteration of genetic information on mRNA is relatively rare, oxidation on mRNAs in vitro and in vivo results in low translation efficiency and aberrant protein products.
Protonation forms peroxynitrous acid, which can undergo homolytic cleavage to form hydroxyl radical and nitrogen dioxide. Advanced Maillard reaction end products are associated with Alzheimer disease pathology.
Harman Oxidative damage to nucleic acids book. This special issue contains five papers. One of the most important classes of these are the quinones. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. We would expect readers to come away from this book with a greater appreciation of the topic, particularly appraising the reader of areas that may not necessarily have been covered in such a volume before.
Bioessays ; — Sung et al.Growing scientific evidence suggests that oxidative stress plays an important role in human health and disease. Under oxidative stress, the excess levels of reactive oxygen species (ROS) may lead to modification of cellular nucleic magicechomusic.com by: 1.
The role of oxidative damage to nucleic acids in the pathogenesis of neurological disease / V. Prakash Reddy [and others] --Nucleic acid oxidation and the pathogenesis of cardiovascular diseases / Maria Grazia Andreassi --Oxidative DNA damage and carcinogenesis / Ryszard Olinski, Marek Foksinski, and Barbara Tudek --The physiological and.
Sep 18, · Radical and Radical Ion Reactivity in Nucleic Acid Chemistry provides the only comprehensive review of the chemistry and biochemistry of nucleic acid radical intermediates.
With contributions by world leaders in the field, the text covers a broad range of topics, including: A discussion of the relevant theory.Oxidatively Pdf DNA and Inflammation.- The Role of Antioxidants in the Prevention of Oxidative Damage to Nucleic Acids. (source: Nielsen Book Oxidative damage to nucleic acids book Summary This book provides up-to-date coverage of selected topics in nucleic acid oxidation.
The topics have been selected to cover everything from basic chemical mechanisms, repair of damage.Nucleic acid modification is well known and may disrupt DNA transcription or foster mutagenesis. Sublethal oxidative damage to unpaired RNA may be particularly relevant to disease states with disrupted translation and its pleiotropic effects.Nucleic Acids Book.
A free online book on the chemistry and ebook of nucleic acids, written by Prof. Tom Brown and Dr Tom Brown (Jnr). The book is ideal for chemistry and biology students and also provides practical information for researchers working in the lab.